IGFBP2 and pancreatic ductal adenocarcinoma: Again, different conclusions about the role of IGFBP-2 have been drawn in other types of cancers such as pancreatic ductal adenocarcinoma (PDAC), where IGFBP-2 promoted EMT: downregulation of N-cadherin and upregulation of E-cadherin followed knockdown of IGFBP-2 [24].