A reduction of IGFBP-2 was correlated with the promotion of epithelial invasion in the progression of cervical cancer [17], and loss of IGFBP-2 was also found at the invasive front of glioblastoma with high 8, line grade suggesting that IGFBP-2 is associated with a less aggressive phenotype [22]. This evidence concerns the gene IGFBP2 and glioblastoma.