The same group also determined that IGFBP-2 mRNA expression levels and the relative expression ratio of IGFBP-2 to IGFBP-3 mRNAs in 97 bladder cancer specimens significantly correlated with pathological stage, lymph node metastasis and vascular invasion [16]. This evidence concerns the gene IGFBP2 and metastatic malignant neoplasm in the lymph nodes.