CD274 and neoplasm: In RIP1-Tag2 mice, a well-established tumor model of endogenous insular cell carcinomas 13, in vivo18F-FDG PET/MRI identified metabolic activation of the spleen caused by the immunotherapy using anti-PD-L1/anti-LAG-3 mAbs combined with (combo) or without (CIT) the adoptive transfer of tumor antigen-specific Th1 cells.