Dercle et al. analyzed the imaging patterns after three months of PD-1 mAb treatment in patients with refractory Hodgkin lymphoma and found that five of the 16 patients (31 %) exhibited new imaging patterns related to PD-1 mAb therapy that did not fit to the RECIST or Lymphoma Response to Immunomodulatory Therapy Criteria (LYRIC) criteria 22. The gene discussed is PDCD1; the disease is Hodgkins lymphoma.