MacroH2A1 is a marker of well-differentiated HCC and of non-tumor/tumor liver tissue senescence 23, 24; however, our previous and current data suggest that macroH2A1 expression is dramatically decreased or absent in a wide range of independent poorly-differentiated human HCCs 16, although the correlation between macroH2A1 immunostaining and HCC encapsulation that we found needs validation in a larger cohort. The gene discussed is MACROH2A1; the disease is hepatocellular carcinoma.