PPARA and obesity due to melanocortin 4 receptor deficiency: In this study, a murine model of obesity-associated dysmetabolism was treated with PPARα/γ dual agonist tesaglitazar as a standard oral formulation or intravenously in liposomes in order to (1) further characterize the cell types that take up liposomes in vivo, (2) investigate whether liposomes could effectively attenuate drug action in the liver and kidney, and (3) determine if tesaglitazar delivered either as a standard oral formulation or in liposomes had anti-inflammatory effects on macrophage populations.