Studies have shown that ANKRD22 is significantly increased in the macrophages of patients with an acute rejection reaction after a renal transplant 32 as well as in the peripheral blood mononuclear cells of patients with pancreatic cancer 33, in basal type I basal-like breast cancer 34, and in non-small cell lung cancer (NSCLC) 35. This evidence concerns the gene ANKRD22 and familial pancreatic carcinoma.