ANKRD22 and colorectal carcinoma: Considering that ANT2, ATP synthase, and an inorganic phosphate carrier form the ATP synthase complex are involved in the transport of ATP/ADP and inorganic phosphate (Pi), we hypothesized that ANKRD22, PDK1, ANT2, and ATP synthase together form a macromolecular complex that co-regulates the energy metabolism of CRC cells.