Since IL-6/IL-6R complex is a pivotal upstream mediator of the JAK-STAT pathway during immune responses and cancer progression 43, and the cytokine analyses also showed that IL6R was indeed one of the most significantly changed cytokines, we hypothesized that JAK/STAT pathway is downstream of knocking-down STING and STING activation through IL6R. This evidence concerns the gene IL6R and cancer.