Our results identified STING as a prognostic factor for GC, and for the first time showed that knocking-down STING and STING activation by 2'3'-c-GAMP both promote TAMs differentiating into pro-inflammatory subtype and induce apoptosis of gastric cancer cells by activating IL6R-JAK-IL24 pathway. The gene discussed is IL6R; the disease is gastric cancer.