IL24 and cancer: First, macrophages indeed increased IL24 secretion cocultured with both human and mouse cancer cells; secondly, knocking-down STING and 2'3'-c-GAMP treatment both further increased IL24 content in supernatants, yet treatment with JAK inhibitor Tofacitinib fully rescued the amount of IL24 to control level; thirdly, overexpressing STING inhibited IL24 secretion by macrophages.