Given the promising virial and non-virial systems to deliver gene-of-interest into target histocytes and tumor cells35, 36, 40, over expressing GATA4 in HCC tumor cells is expected to elicit dramatic shrinkage of HCC tumors through two ways: suppression of the function of β-catenin; expression of tumor suppressor genes. The gene discussed is GATA4; the disease is hepatocellular carcinoma.