This notion is supported by five lines of evidence: (i) a previous report has classified GRWD1 and RPL11 as potential RNA binding proteins45, supporting the possibility that GRWD1 and RPL11 may interact with lncRNAs; (ii) PiHL directly binds with GRWD1 and RPL11 via its 3' and 5' domain, respectively; (iii) PiHL localized in the nucleolus of CRC cells; (iv) PiHL increases the binding of the GRWD1/RPL11 complex and subsequent promote p53 ubiquitination; (v) Overexpression of PiHL does not affect p53 protein levels when MDM2 was depleted. Here, MDM2 is linked to colorectal carcinoma.