Data fitting to a model of one exponential growth (y = y0 + A(1 - e-x/t)) presented that the time constants (t) and relative amounts of plasma Aβ (A) were 0.19±0.02 h and 22.3±0.2 (WT mice), 0.20±0.02 h and 23.5±0.4 (untreated APP/PS1 mice), 0.17±0.02 h and 33.3±0.6 (CFA-treated AD mice, P<0.1 vs WT or APP/PS1), respectively. Here, PSEN1 is linked to Alzheimer disease.