As VHL is a component of the HIF1α pathway, as hypoxia is one of the main functions affected in solid tumors (i.e. 44), and having VHL increase an impact on triple negative BC cell growth 45, we speculated that the As miR-429 treatment, increasing mRNA of VHL, impacts on HIF1α protein degradation, leading to cell proliferation inhibition and to the block of metastatic potential of the HER2+ cells. This evidence concerns the gene HIF1A and breast cancer.