In particular, we identified three miRNAs, namely Hsa-miR-190, Hsa-miR-429 and Hsa-miR-584 (indicated from here on as miR-190, miR-429 and miR-584, respectively), having a higher degree centrality in HER2+ BC, being able to control the highest number of genes in coupled functional pathways. This evidence concerns the gene ERBB2 and breast cancer.