FSHR and hypogonadism: As a transcription co-regulator, CITED enhances the activity oftranscription factors such estrogen receptors[36].The FSHR variant rs2268361 was determined to be related to the ovarian response to FSH [37].Inactivating mutations of FSHR lead tohypergonadotropic hypogonadism and preantral-stage follicle stagnation [37].