Therefore,it is of interest to study the genotype and allele frequency for six gene variants (THADA rs13429458, TOX3 rs4784165, FSHR rs2268361, YAP1 rs1894116, RAB5B rs705702, and HMGA2rs2272046) in patients with PCOS in western Saudi population. This evidence concerns the gene RAB5B and polycystic ovary syndrome.