ESR1 and polycystic ovary syndrome: Accordingly, we detected significant correlation of THADA rs13429458 variant, TOX3rs4784165 variant with the OA+PCOM subgroup, and HMGA2 rs2272046 variant with the HA+PCOM subgroup.TOX3 and HMGA2 genes are well-known contributors to PCOS through enhancement ofthe activity of transcription factors such as the estrogen receptor [36] and promoting the proliferation of granulosa cells [38], respectively.