Moreover, as Aβ-induced ER stress is considered an indirect effector of the Aβ-neurotoxicity in early stages of AD [34], our data suggest that STARD1 overexpression in the hippocampus may be a potential early molecular event associated with AD, as strengthened by the increase seen in DS, an accelerated genetic form of AD. The gene discussed is STAR; the disease is Alzheimer disease.