Next, the expression of key genes of the Wnt signaling pathway (β-catenin, C-myc, CCND1), inflammatory factors (interleukin-6 [IL-6], IL-8), and RA marker genes (fibronectin and MMP3) was further determined when Dnmt3b expression was altered. This evidence concerns the gene CXCL8 and rheumatoid arthritis.