Studies investigating CYP2J2 polymorphism in coronary artery diseases revealed an increase risk in the German population, decreased risk in African Americans, and no association in Caucasians and the Swedish population.18, 19, 21, 22 Polonikov et al. showed an increased risk of hypertension in Russian patients; however, this association couldn’t be confirmed in African Americans or Caucasians.23, 24, 25 Polonikov et al. also described a sex-specific relationship between CYP2J2 polymorphism and hypertension in female Russian patients.26 This evidence concerns the gene CYP2J2 and hypertensive disorder.