We found that miR-1-3p, miR-155-5p, miR-190a-5p, and miR-548ar-3p associated with fibrotic genes such as COL1A1, COL14A1, and COLQ. Among them, miR-190a-5p (downregulated in HF samples) regulated the largest number (n = 16) of upregulated DEGs, most of which are involved in ECM, suggesting miR-190a-5p may be a main regulator in ECM associated with HF. This evidence concerns the gene COLQ and hydrops fetalis.