Using the same murine model, Tao et al. demonstrated that IL-10 inhibition significantly augmented the therapeutic efficacy of adoptive B-cell transfer, as demonstrated by increased trafficking of CD8 + T cells into the tumour microenvironment as well as in vitro antigen-specific B-cell dependent, FasL-mediated tumour cell killing [31]. The gene discussed is CD8A; the disease is neoplasm.