Our impedance-based real-time cell analysis showing that cytotoxic T-lymphocyte activity is dramatically exacerbated when highly aggressive cancer cells overexpressing PD-L1 in almost 100% of the cells were previously exposed to RSV strongly suggests that, beyond promoting abnormal PD-L1 glycosylation, RSV might be targeting the immunosuppressive signaling of PD-L1 by additional mechanisms. The gene discussed is CD274; the disease is cancer.