With the stimuli of CSE, Cav-1 also negatively regulates the autophagic label protein LC3B (autophagic protein microtubule-associated protein 1 light chain-3B) in COPD (chronic obstructive pulmonary disease) disease, thus protecting the epithelial cells from apoptosis and autophagy [29]. Here, MAP1LC3B is linked to chronic obstructive pulmonary disease.