Consistent with a previous report showing that knockdown of BRD4 decreased viability in the AR-positive but not AR-negative cell lines [37, 39], we found that only AR-positive cells were sensitive to JQ1-induced apoptosis and cell cycles arrest in G1 phase; we did not find a significant effect on the growth in AR-negative PCa cells treated with JQ1. Here, BRD4 is linked to posterior cortical atrophy.