To interrogate the combined effect of these two epigenetic inhibitors on PCa, we first examined the expression of BRD4 and LSD1 in androgen-sensitive AR-positive PCa cell lines (LNCaP and LAPC4), AR-positive but castration-resistant cell lines (22Rv1 and C4-2) and AR negative prostate cell lines (PC3 and DU145) (Figure 1A). This evidence concerns the gene BRD4 and posterior cortical atrophy.