Indeed, the model predicts that individual infection of initially sensitive bacteria with Acr-negative phages leads to rapid phage extinction due to the evolution of CRISPR-based resistance (Figure S5A), whereas Acr-positive phages avoid extinction across a large range of φ and γ−1 values (Figures S5B–S5G consistent with Figures 1A and 1B, i.e., no differences between Acr variants in this context). The gene discussed is ACR; the disease is infection.