As a result, our study elucidated that the cinnamon supplementation in the way of three grams per day for 8 weeks has not remarkable effect in reduction of NF-kB, SIRT1, hs-CRP, IL-6 and TNF-α plasma levels which have key role in atherogenicity in type 2 diabetes patients. Here, SIRT1 is linked to type 2 diabetes mellitus.