Moreover, Li et al. demonstrated that SPOP destabilized SRC-3 by hastening its polyubiquitination and proteasomal degradation in a phosphorylation-dependent manner in BC cells, thereby significantly reducing the levels of some molecules involved in SRC-3-mediated oncogenic signaling such as IGF-1 and MMP-2 [26]. The gene discussed is NCOA3; the disease is breast cancer.