For example, miR-145 and miR-543 reduced endogenous SPOP levels in human CRC, BC, CC, HCC and GC cells by directly targeting a conserved putative binding site in the 3′-untranslated regions (3′-UTRs) of SPOP transcripts, promoting the invasion and migration of cancer cells [135, 136]. The gene discussed is SPOP; the disease is gastric cancer.