According to TCGA data analysis, upregulation of CD44 and OPN shows a trend for the worst prognosis in esophageal carcinomas and CIN subtype of gastric carcinomas, which are predominantly located near human gastroesophageal junction29 Furthermore, in both cases disease/progression-free survival of patients is significantly shorter. The gene discussed is CD44; the disease is cervical squamous intraepithelial neoplasia.