There is also evidence of reduced histone acetylation in ALS (Cudkowicz et al. 2009; Janssen et al. 2010; Liu et al. 2013) and in transgenic mouse models of fALS1 due to SOD1 mutations (Rouaux et al. 2003; Ryu et al. 2005). The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.