High neutrophil/lymphocyte ratio (NLR), which is typically measured in conventional blood tests, is associated with poor prognosis in cytotoxic T lymphocyte antigen-4 (CTLA-4) antibody-treated patients with malignant melanoma [33] and in PD-1 antibody-treated patients with various cancer [34, 35]. This evidence concerns the gene CTLA4 and melanoma.