The estimate of the central volume of distribution (1.1 L) was lower relative to published values for mAbs (2.4 to 5.5 L) which may have been due to the lack of PK data in T1D subjects following IV administration as well as rapid binding of PF-06342674 to IL-7Rα in the central compartment. Here, IL7R is linked to type 1 diabetes mellitus.