CD4 and cancer: Annexin A2 is involved in the EMT process in cancer and colocalizes with E-cadherin in the presence of TGFβ.39 Immunofluorescence staining showed that Annexin A2 and E-cadherin were uniformly distributed on TECs in the presence of TGFβ; however, Annexin A2 tended to aggregate on the membrane for enhanced binding to CD147 on T cells when TECs were cocultured with CD4 + CD147 + T cells, and in this condition, the expression of E-cadherin was decreased (Fig. 5e and Sup.