CNR2 and neuroblastoma: Interestingly, we noted that the CNR2 ligand GW405833 activated genes regulated by the rhodopsin-like G-protein coupled receptors (GPCRs), which is a family of GPCRs that includes the cannabinoid receptors (Supplementary Fig. 4H), and the effect on neuroblastoma cells could be blocked by CNR2 antagonist (Supplementary Fig. 4C, D).