It inhibits alveolar bone loss and downregulates the expression of IL-1β in rat periodontitis.155 Plumbagin is extracted from the roots of Plumbago zeylanica L. It significantly decreases the expression of TNF-α, IL-1β and IL-6 and decelerates bone destruction in rats with chronic periodontitis.156. The gene discussed is IL1B; the disease is periodontitis.