The IL-1β rs16944 polymorphism is associated with susceptibility to periodontitis in the European20 and the Chinese population.26 However, another report showed no significant association between the IL-1β rs16944 polymorphism and CP susceptibility.27 The link between the IL-1β rs1143627 polymorphism and susceptibility to periodontitis is even weaker. Here, IL1B is linked to periodontitis.