Some ameloblastic carcinomas in humans have been proposed to develop from ameloblastomas.19 Our results suggest that increased IKKβ expression provokes NF-κB activation and a strong inflammatory response that could contribute to the tumoural transformation of the odontogenic epithelium through the uncontrolled release of inflammatory cytokines and facilitate the development of a secondary ameloblastic carcinoma in a pre-existing ameloblastic odontoma, although the existence of other driving factors cannot be ruled out. Here, NFKB1 is linked to ameloblastic carcinoma.