Not surprisingly, miRNA deregulation is an important player in cancer pathogenesis, including oral SCC and head and neck cancer.15 The miRNAs that were downregulated by IKKβ overexpression included let-7b, let-7c, miR-125b, miR-21 and miR-34c; interestingly, all of these miRNAs are functionally related to tumoural transformation. This evidence concerns the gene IKBKB and head and neck cancer.