In another Ink4a/ArfKO/K5-IKKβ mouse, we found an ameloblastic odontoma with foci of secondary ameloblastic carcinoma around the denticles (Fig. 5b, arrowheads), which developed microscopic metastatic foci in the lung, showing a cellular pattern similar to secondary ameloblastic carcinoma with abundant areas of squamous differentiation (Fig. 5c, arrows). Here, IKBKB is linked to ameloblastic carcinoma.