In the context of our study on the role of IKKβ in skin cancer, we generated cohorts of K5-IKKβ transgenic mice that also lacked either p53 in stratified epithelial tissues (p53EKO/K5-IKKβ mice) or p16 and p19 in every cell (Ink4a/ArfKO/K5-IKKβ mice). The gene discussed is KRT5; the disease is skin cancer.