The ameloblastic odontomas showed activation of the canonical WNT/β-catenin, STAT3 and AKT signalling pathways in the ameloblastic epithelium, as they exhibited nuclear β-catenin and STAT3 staining, especially in the foci of secondary ameloblastic carcinoma (insets in Fig. 3g, h), which were also positive for staining with an antibody specific for phospho-AKT (Ser473), an active form of AKT (Fig. 3i). This evidence concerns the gene AKT1 and ameloblastic carcinoma.