miR-203 is differentially expressed in the epithelium and mesenchyme of dental primordia, and hence, it could be important in tooth organogenesis.27 Thus, the overexpression of miR-203 found in K5-IKKβ oral keratinocytes could contribute to the development of ameloblastic odontomas and secondary ameloblastic carcinomas observed in p53EKO/K5-IKKβ and Ink4a/ArfKO/K5-IKKβ mice. Here, CDKN2A is linked to ameloblastic carcinoma.