IKBKB and ameloblastic carcinoma: Therefore, p53EKO/K5-IKKβ mice and Ink4a/ArfKO/K5-IKKβ mice represent good models for studying the pathogenesis of the progression to secondary ameloblastic carcinoma from pre-existing ameloblastic odontoma and are also very useful for testing the efficacy of IKKβ or WNT/β-catenin inhibitors in preventing odontogenic tumour development.