BMAL1 and infection: Therefore, to explore the role of the circadian clock within the myeloid system in lung immunity against infection, we utilized mice lacking the core clock component Bmal1 in myelomonocytic cells (LysM-Bmal1−/− alveolar macrophage penetrance confirmed SI Appendix, Fig. S1 A, Left) or macrophages (CX3CR1-Bmal1−/−, SI Appendix, Fig. S1 A, Right) (Fig. 1 A and B).