Our study found that both the carriers of CYP2C19*2 and CYP2C19*3 mutant allele showed attenuated response to clopidogrel therapy, after adjusted for age, sex, BMI, hypertension, hyperlipidemia, type 2-DM,smoking, we also found a synergic effect between the two alleles mutation on Clopidogrel resistance, both intermediated metabolizer (*1/*2,*1/*3)and poor metabolizers(*2/*2,*2/*3) all increased the Clopidogrel resistance as compare with normal metabolizers(*1/*1). The gene discussed is CYP2C19; the disease is hyperlipidemia.