Since little is currently known about the effects of exercise on EPC function, we aimed to explore the effects of aerobic training (AT), resistance training (RT) or a combination of aerobic and resistance training (AT+RT) on the function of EPCs and the protein expression of caveolin-1, PI3K and AKT in mice with type 2 diabetes. The gene discussed is CAV1; the disease is type 2 diabetes mellitus.