The data revealed that (i) RT, AT and a combination of both can significantly improve the proliferative functions of EPCs in mice with type 2 diabetes and that AT+RT induced the greatest improvement in EPC adherence; (ii) AT+RT induced increases in caveolin-1 and PI3K AKT; and (iii) knockdown of caveolin-1 abolished the positive effect of AT+RT on the functions of EPCs and protein expression (caveolin-1, PI3K, AKT). The gene discussed is CAV1; the disease is type 2 diabetes mellitus.