The apoptosis-related proteins including CASP3, Bax, Bcl-2 and XIAP, and the proliferation and metastasis-related proteins including VEGF and MMP-2 in protein level of colon cancer cells (HCT29, LS174T, LOVO and CT26 cells) transfected with LINC00662 overexpression or LINC00662 inhibition were detected by means of western blotting (Fig. 3a). The gene discussed is BCL2; the disease is malignant colon neoplasm.