It is reported that lncRNA HOXD-AS1 influences the proliferation and invasion of hepatocellular carcinoma cells by regulating the activation of ERK signaling pathway [20]; miR-98 inhibits cell growth and invasion in retinoblastoma by targeting ERK signaling Pathway [21]; cicrRNA_006528 promotes the occurrence and development of breast cancer by activating ERK signaling pathway [22]; ectonucleoside triphosphate phosphohydrolase-7 (ENTPD7) inhibit the proliferation of lung cancer by inhibiting the activation of ERK signaling pathway [19]. The gene discussed is MAPK1; the disease is retinoblastoma.