Next, high expression of LINC00662 prominently elevated the expressions of CLDN8, IL22 and phosph-ERK in protein level of colon cancer cells including HCT29, LS174T, LOVO and CT26 cells, however, the expressions of CLDN8, IL22 and phosph-ERK in protein level of LINC00662 overexpression transfected colon cancer cells were inhibited by miR-340-5p overexpression (Fig. 8i-l). The gene discussed is CLDN8; the disease is malignant colon neoplasm.