Furthermore, cancer cells can recruit immunosuppressive cells, such as tumor-associated macrophages (TAM), regulatory T cells (Treg) and myeloid-derived suppressor cells (MDSCs) [8], and express or secrete immunosuppressive factors such as indoleamine 2,3-dioxygenase-1 (IDO1), and programmed death-ligand 1 (PD-L1) [9], all of which promote dysfunctional immune responses and shape a highly suppressive tumor microenvironment, ultimatey leading to exhaustion and/or apoptosis of PD-1-expressing cells via the activation of the PD-L1 signalling pathway [8, 10, 11]. This evidence concerns the gene CD274 and neoplasm.