Co-culture of sialyl-Tn+ cancer cell line and M-CSF–induced human macrophages or Siglec-15+ myeloid cell line enhanced the myeloid cell production of TGF-β (a pleiotropic cytokine that promotes epithelial-mesenchymal transition and metastasis of cancer cells) [43], which was dependent on DAP12 and SYK. Here, SYK is linked to cancer.