Multivariate regression analysis revealed that both circ_0003204 in the plasma EVs and LDL-C level were correlated with cerebral atherosclerosis after adjusted for gender, age, history of drinking and smoking, TC, HDL-C, TG, hypertension, diabetes, HCY, Lp-PLA2 and miR-370 expression (Additional file 1: Table S4). The gene discussed is PLA2G7; the disease is hypertensive disorder.