Of importance, none of the laboratory parameters in the final BSI screening tool require the clinician to have a pre-existing suspicion of infection (e.g. lactate, CRP, ESR); since the whole point and value of the BSI screening tool is to enable early identification of older patients with a high probability of BSI in whom blood cultures and other confirmatory laboratory parameters (e.g. lactate, CRP, ESR) should be drawn. Here, CRP is linked to infection.