In one scrotal EMPD, a pathogenic MUTYH gene mutation (G393D) was found representing a germline variant (MUTYH‐associated polyposis is an autosomal recessive polyposis syndrome caused by bi‐allelic pathogenic germline variants in the MUTYH gene.11 No other CNV or gene fusions were detected in any of the tested cases. This evidence concerns the gene MUTYH and extramammary Paget disease.