Similar to MPD from our cohort, androgen receptor (AR) over‐expression is commonly seen in EMPD (54%‐90%).24, 27, 30 AR protein expression has also been shown to correlate with the invasiveness in EMPD.3 A successful treatment with combined androgen blockade (bicalutamide/targeted anti‐AR/) and leuprolide acetate (LH‐RH analogue) has been published in a single case report.31 Our study further confirms earlier observations of frequent AR expression.24, 32 We also report for the first time, the presence of the ARv7 transcript, a pathogenic splice variant of AR in single cases of EMPD and MPD. Here, AR is linked to extramammary Paget disease.