ESR1 and extramammary Paget disease: Garganese et al recently reported ER positivity in 70% of vulvar EMPD.27 Importantly, this may represent a potential therapeutic target as Iijima et al reported a successful treatment of ER + scrotal EMPD with tamoxifen.28 In addition, Wachter et al recently reported ER expression in 27% of MPD.29