Selected cases of EMPD (with amplified ERBB2/HER2 gene) have been successfully treated with trastuzumab alone or in combinations with chemotherapy.4, 15, 16, 17, 18, 19, 20, 21 In contrast to MPD, we found overexpression and HER2 gene amplification in a minority of cases, and a co‐amplification with TOPO2 in a single case of vulvar disease. This evidence concerns the gene ERBB2 and extramammary Paget disease.