Interleukin-1B (IL1B) and Interleukin-6 (IL6) took part in pathways which are the NOD-like receptor signalling pathways, cytokine-cytokine receptor interactions, TNF-signalling pathway, and Rheumatoid arthritis pathways; C-X-C motif chemokine ligands (CXCL) 1, 2, and 3 took part in 2–3 pathways including the TNF-signalling pathway, cytokine-cytokine receptor interactions and NOD-like receptor signalling pathways etc. Here, TNF is linked to rheumatoid arthritis.