IL1B took part in 5 pathways, and IL6 took part in 4 pathways which are NOD-like receptor signalling pathways, cytokine-cytokine receptor interactions, TNF-signalling pathway, and Rheumatoid arthritis pathways; CXCL1, CXCL2, and CXCL3 took part in 2–3 pathways including the TNF-signalling pathway, cytokine-cytokine receptor interactions, and NOD-like receptor signalling pathways. The gene discussed is TNF; the disease is rheumatoid arthritis.