EGFR and myopia: Epidermal growth factor receptor (EGFR) is a member of the ErbB family of RTKs and regulates cellular proliferation of primary SF through intracellular signaling pathways involving the classical mitogen-activated protein kinase pathway.48 Atropine has been shown to reduce EGFR activity in mouse primary SF in a dose-dependent manner.48 Thus, atropine is a shotgun approach to myopia treatment.