In multivariable analysis, compared with the ER-positive/PR-positive subtype, the ER-positive/PR-negative, ER-negative/PR-positive, and ER-negative/PR-negative subtypes were significantly associated with a 36% (HR, 1.36; 95% CI, 1.34-1.38), 61% (HR, 1.61; 95% CI, 1.55-1.67), and 72% (HR, 1.72; 95% CI, 1.70-1.75) increased risk of BC-specific death, respectively (Table 2). The gene discussed is ESR1; the disease is breast cancer.