Data from the British Society for Rheumatology Biologics Register for RA (BSRBR-RA) did indicate statistically and clinically significant reductions in levels of fatigue for those patients treated with anti-TNF-α [34]; however, despite these improvements, there were still a substantial number of patients who achieved disease remission that reported high levels of fatigue [35]. This evidence concerns the gene TNF and rheumatoid arthritis.