The occurrence of 4 gene mutations in PCLO, GOLGA8J, EDRF1, and ASF1A on an initiator clone with TP53, PTEN, RLF, DLG2, and YY2 mutations might have resulted in the establishment of the founder clone, which then developed separately along germ cell and hematopoietic lines by adding GCT- and AML-specific gene mutations, respectively. The gene discussed is PTEN; the disease is acute myeloid leukemia.