Some authors have observed that STAG2 encompasses transcriptional co-activation domains and motifs that may affect cell cycle gene expression [59, 60], but knock-in and knock-out studies found only a slight effect of STAG2 expression on cellular growth in glioblastoma, human colorectal, and bladder cancer cells [28, 50]. This evidence concerns the gene STAG2 and urinary bladder carcinoma.