However, when we focus on the diagnostic ability of HCC from SHC, the serum AFP (AUC = 0.889, sensitivity 76.9%, specificity 92.1%) was better than plasma HSP90α (AUC = 0.601, sensitivity 63%, specificity 54.4%) for distinguishing the HCC patients from those with SHC (Fig. 3c). This evidence concerns the gene AFP and hepatocellular carcinoma.