However, this result is inconsistent with the recent study that showed plasma HSP90α (AUC 0.965, sensitivity 93.3%, specificity 90.3%) improved significantly compared with AFP (AUC 0.887, sensitivity 61.1%, specificity 96.3%) for the diagnostic ability of distinguishing HCC or early-HCC from non-liver cancer control patients [9]. This evidence concerns the gene AFP and hepatocellular carcinoma.