AFP and hepatocellular carcinoma: The results of ROC curve analysis showed that by comparison with AFP (AUC 0.922, sensitivity 81.18%, specificity 93.91%, cut-off 5.38 ng/mL), the plasma HSP90α levels (AUC 0.836, sensitivity 67.07%, specificity 90.43%,cut-off 69.10 ng/mL) have a poor performance in the diagnosis of HCC from healthy donors.