HSP90AA1 and hepatocellular carcinoma: Even so, the combination of HSP90α and AFP significantly improved the diagnostic efficiency for HCC compared to the use of a single marker in both, the current study (AUC 0.943, sensitivity 85.89%, specificity 98.26%) and the previous study (AUC 0.977, sensitivity 93.7%, specificity 94.4%) [9].