Furthermore, the IMpower150 trial demonstrated superior PFS and OS for carboplatin/paclitaxel, bevacizumab and the PD-L1 blocking antibody atezolizumab vs. carboplatin/paclitaxel and bevacizumab in metastatic nonsquamous NSCLC, regardless of PD-L1 status and EGFR or ALK genetic alteration status [20]. This evidence concerns the gene CD274 and non-small cell lung carcinoma.