Moreover, the expression levels of mTOR and phosphorylated 4EBP1 and 70S6K were remarkably reduced in the HCC samples of mice with combined treatment of AMSC-Exo-199a and Dox compared with that of the mice treated with AMSC-Exo-67 and Dox (Fig. 5d). Here, MTOR is linked to hepatocellular carcinoma.