Compared to AMSC-Exo-67-treated HCC cells, the mTOR expression was consistent with the phosphorylation level of its downstream proteins, 4EBP1 and 70S6K, which were all significantly decreased in AMSC-Exo-199a-treated cells (Fig. 4c). The gene discussed is EIF4EBP1; the disease is hepatocellular carcinoma.