Moreover, mTOR overexpression could reverse both of the AMSC-Exo-199a-reduced phosphorylation of 4EBP1 and 70S6K in HCC cells and the reduced chemoresistance of HCC cells by AMSC-Exo-199a treatment, further confirming that AMSC-Exo-199a enhances HCC chemosensitivity does by suppressing mTOR expression and its subsequent signaling activation. Here, EIF4EBP1 is linked to hepatocellular carcinoma.