For example, the predicted target genes related to depression include NOVA1 (regulated by miR-193-5p and miR-1224) [16], Rgs4 (regulated by miR-193-5p and miR-466b-5p) [17–20], zinc-finger protein (regulated by miR-6332, miR-466b-5p, and miR-1224) [21], PBX1 (regulated by miR-466b-5p and miR-6332) [22], SLC8A1 (regulated by miR-107-5p, miR-135a(b)-5p, and miR-135b-5p) [23], PTK2 (regulated by miR-107-5p and miR-135b-5p) [24], and Tiam1 (regulated by miR-107-5p and miR-135b-5p) [25]. This evidence concerns the gene RGS4 and major depressive disorder.