Let-7c was shown to directly bind to the Basic Leucine Zipper Transcription Factor-1 (BACH1), a strong repressor of the anti-inflammatory and anti-oxidant protein Heme Oxygenase 1 (HO-1), and downregulated both DENV-2 (strain New Guinea C) and DENV-4 (strain V3361–1956) infections. This evidence concerns the gene HMOX1 and infection.